CORE™ 20 kDa ultrafiltration membrane selectively retains high-value plasma proteins like fibrinogen, albumin, and growth factors while efficiently removing smaller waste molecules such as free amino acids and metabolic byproducts. This results in a highly concentrated, bioactive protein solution that enhances regenerative treatments by preserving essential healing factors without dilution or degradation.
Polysulfone is an ideal material for protein filtration due to its high chemical stability, low protein binding properties, and superior permeability, ensuring efficient retention of target biomolecules while minimizing loss. Its biocompatibility and durability make it perfect for medical and laboratory applications, providing consistent filtration performance without compromising protein integrity.
The low priming volume in the CORE™ Ultrafiltration System allows for efficient processing of smaller plasma volumes, minimizing sample loss while preserving key proteins and growth factors. This feature is especially beneficial for point-of-care and regenerative applications, ensuring higher protein recovery and concentration even from limited plasma samples.
The closed system processing with self-sealing valve ports in the CORE™ Utrafiltration System ensures sterility by minimizing exposure to contaminants, reducing infection risks during plasma concentration. This design also enhances usability by enabling seamless operation for safe and efficient sample handling with minimal sterile barriers.
CORE™ Ultrafiltration system
Precision Protein Retention
Low-volume 20 kDa plasma ultrafiltration efficiently concentrates plasma proteins by selectively retaining key biomolecules like albumin, fibrinogen, and growth factors, while removing excess fluid and small waste molecules. Its rapid processing and minimal sample loss make it ideal for point-of-care applications like PRP, and other autologous biologics. The device enhances bioactivity by preserving protein functionality without the need for harsh chemical treatments. This improves the therapeutic potential for tissue healing and repair. Additionally, its compact and scalable design allows for seamless integration into clinical and research workflows, optimizing plasma-based treatments and biomarker studies.
Fibrinogen plays a crucial role in wound healing and tissue regeneration by forming a fibrin scaffold that supports cell migration, angiogenesis, and extracellular matrix deposition. It enhances hemostasis and clot stability, providing a structural framework that promotes stem cell adhesion and growth factor retention at the injury site. Additionally, fibrinogen modulates inflammation by regulating immune cell activity, reducing excessive inflammatory responses while facilitating tissue remodeling. Its ability to create a biocompatible and bioactive matrix makes it valuable for regenerative applications, including tendon and ligament repair, wound healing, and orthopedic tissue engineering.
Alpha-2-Macroglobulin (A2M) is a broad-spectrum protease inhibitor that helps regulate inflammation by neutralizing catabolic enzymes like MMPs and cytokines, which contribute to tissue degradation. By preventing excessive inflammation and cartilage breakdown, A2M is particularly beneficial in osteoarthritis, tendon injuries, and joint degeneration. It also promotes a pro-healing environment by reducing oxidative stress and supporting tissue regeneration. As an autologous biologic, A2M-based therapies offer a natural, targeted approach to slowing degeneration and enhancing recovery in musculoskeletal and orthopedic applications.
Immunoglobulins can help regulate the immune system by potentially increasing the expression of inhibitory FcγRIIB receptors on immune cells, like macrophages. This can increase the threshold for activation of these cells, which can help reduce the overall inflammatory response. Immunoglobulins also play a crucial role in modulating inflammation, preventing infections, and promoting immune balance at the injury site. These proteins help reduce excessive inflammatory responses, creating a more favorable environment for tissue repair and regeneration. By neutralizing pathogens and regulating immune cell activity, immunoglobulins protect regenerating tissues from immune-mediated damage.
